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Pharmaceutical Industry

Drug Production and Material Characterization


Material characterization is an integral part of pharmaceutical manufacturing. Correct characterization of the materials used to produce drugs ensures the quality of the end product as well as the efficiency of the manufacturing process. Some of the key attributes of pharmaceutical industry ingredients that must be characterized accurately are purity, particle size, shape and polymorphic form.

Pharmaceutical compounds have the capability of existing in more than one form or crystalline structure, and these polymorphs can exhibit different biopharmaceutical properties and therefore selecting the optimum solid form is very crucial for their development.

Particle Size Distribution

Particle size distribution of active ingredients and excipients is vitally important. In respect of adsorption rates, dissolution and content uniformity there is an established relationship between particle size and drug performance. Proper matching of particle size of active ingredient and excipient is also equally important.

Bulk Properties

Physical properties of pharmaceutical compounds generally have an impact on their bulk properties, processability, formulation performance, appearance and stability; which makes the solid state characterization so important.

Nanoparticles

Nano-scaled pharmaceutical products have been receiving a great focus for the last couple of decades and medical companies are introducing nanoparticles in areas like gene therapy and protein analysis. Using nanotechnology has some unique therapeutic advantages; for example reducing the size of particles may enable them to pass through certain biological barriers or membranes and reach the targeted cells. Of particular interest to pharmaceutical chemists is that stability of nanodispersions.

 

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Pharmaceutical Material Characterization